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Keep track of Intently (two)pentobarbital will lessen the level or influence of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Potent CYP3A4 inducers may perhaps decrease suvorexant efficacy; if increased suvorexant dose necessary, never exceed 20 mg/daypentobarbital will lower the level or outcome